How Long Does DMT Last?

How Long Does DMT Last in the system

How Long Does DMT Last in the System, When smoked or vaped, DMT lasts less than 45 minutes and up to 12 hours in the form of ayahuasca. It can be detected in the body for up to 24 hours.

MT (dimethyltryptamine) is a highly potent psychoactive chemical found in a wide range of plants and animals.

When we eat DMT, it is usually eliminated before it has an impact. However, if we smoke or vape DMT, it can breach the blood-brain barrier and exert its effects before the body can counteract it.

Pure N, N, DMT, or 5-MeO-DMT excursions normally last no more than 45 minutes (usually closer to 30).

DMT in herbal form, such as ayahuasca, can last significantly longer (up to 12 hours). DMT does not linger in the body for long and is completely removed within a day of use.

Key Highlights: How Long Does DMT Last?

  • A DMT experience can last up to 45 minutes (whether smoked or vaped).
  • DMT has an immediate effect (whether smoked or vaped).
  • DMT is present in the blood for 2 hours.
  • DMT can be found in the urine for up to 24 hours.
  • DMT can be found in the hair for up to 90 days.

How Long Does DMT Take to Kick In?

Celerity (think “acceleration”) is a term used in the field of psychedelics to describe how quickly a chemical takes effect.

DMT has an extremely high celerity, which means it takes action nearly instantly (when smoked). It’s the hallucinogenic equivalent of a drag racer. It takes off with incredible velocity, yet the race is finished just as fast as it began.

DMT users will take a slow, deep inhalation and hold it for 15 or 20 seconds before exhaling. The impacts are already in motion by the time they breath. You’ll be in another realm in around 60 seconds.

Intravenous DMT is just as quick, hitting in with full power at the 20-second point.

DMT in other forms, such as ayahuasca, takes significantly longer. The active chemicals must first travel through the stomach, then into the small intestines, and finally into the circulation. Ayahuasca takes around an hour to begin feeling the effects, which build steadily over the next 1-2 hours.

What Factors Affect DMT?

Absorption is the primary factor that influences the celerity, or onset time, of DMT. Other considerations include your particular DMT tolerance and the state of your intestinal health (for oral DMT alone).

1. Absorption

DMT is complete and ready to use. It does not need to be “activated” in the same way as psilocybin from magic mushrooms or 1P-LSD do. DMT begins pressing the 5-HT2C receptors and generating psychedelic effects as soon as it reaches the brain.

Absorption is the key determinant of the time it takes for DMT to manifest its effects. The time it takes for DMT to reach the bloodstream is the time it takes for its effects to kick in.

Smoked or vaped substances are absorbed extremely rapidly. These molecules go via the small capillaries that carry CO2 and oxygen into and out of the bloodstream. DMT is already on its way to the brain in a matter of seconds.

DMT (ayahuasca) taken orally takes significantly longer simply because it takes longer to absorb. When taking drugs orally, there are many more stages involved than when they are breathed or injected.

2. DMT Tolerance

The more DMT you take, the less effective it becomes. Tolerance develops quickly, and most individuals discover they can’t experience the full benefits of DMT if they consume it more than once per week.

If you’ve recently taken DMT, the onset time and intensity of the effects will be delayed and milder than in the first session.

3. Digestive Health Status (Oral Only)

When taking DMT orally, such as ayahuasca, your digestive state will have a significant influence on the onset time. People who are unable to absorb DMT owing to inflammation or irritation will have to wait longer to feel its benefits.

The contents of your stomach might also have an effect on onset time. If you take ayahuasca on an empty stomach, it will take effect much faster than if you take it immediately after a substantial meal.

How Long Does the DMT Experience Last?

DMT disappears as quickly as it appears. DMT that is smoked, vaped, inhaled, or insufflated seldom lasts more than 45 minutes. Most folks will spend closer to 30 minutes from start to finish.

This is why DMT is sometimes referred to as “the business trip” – it is intense yet fleeting. Within the period of a conventional lunch hour, you can shift from normal waking awareness to encountering interdimensional machine elves and back again.

The length is also affected by the DMT dosage. The more you consume, the longer it takes for the body to digest and remove it from the system.

Here’s a summary of how long different types of DMT may be expected to last:

  1. DMT injection — lasts up to 30 minutes
  2. DMT can be smoked or vaped for up to 45 minutes.
  3. DMT insufflated — Lasts up to 1 hour
  4. Oral DMT (Ayahuasca) — Lasts up to 12 hours, with some aftereffects lasting up to 12 hours longer.

How Long Do Different Kinds of DMT Last?

DMT comes in a variety of forms. N, N, DMT, and 5-MeO-DMT are the most common types.

The duration of each of these DMT forms differs just slightly. Some argue that the N,N,DMT isomer lasts longer, while others argue that 5-MeO-DMT lasts longer – the judgment is still out on this one. In any case, the change is too little to be significant in any case.

The same can’t be said for other forms of DMT:

  1. 5-Bromo-DMT — Also known as “SpongeBob DMT” because of its prevalence in several sea sponges. This compound can be smoked for up to 45 minutes.
  2. 4-HO-DMT — This is the chemical term for psilocin, which is found in magic mushrooms. This chemical has an oral half-life of up to 8 hours.
  3. 4-AcO-DMT — This molecule is a psilocin (magic mushroom) prodrug. It has an oral duration of up to 8 hours.
  4. Bufo Toad Venom — The toad Bufo alivarius secretes a combination of bufotenin and 5-MeO-DMT. The effects of smoking or vaping might last up to 45 minutes.

How to Make DMT Last Longer

When the chemical responsible for breaking down DMT (called MAO) is suppressed, it lasts longer. This can be accomplished by combining DMT with another plant or chemical that inhibits this enzyme.

This is how ayahuasca may last up to 12 hours, as opposed to vaped DMT, which only lasts 45 minutes.

DMT is rapidly degraded by an enzyme known as monoamine oxidase (MAO). It’s the same enzyme that degrades serotonin and dopamine when they’re no longer needed.

Ayahuasca is made up of an MAO inhibitor (the ayahuasca vine) and a DMT supply (often mimosa or chacruna). For several hours, the MAO inhibitor prevents the enzyme from degrading the DMT, thus extending the effects and intensity of the DMT.

Because smoking freebase DMT lacks this advantage, it seldom lasts more than a few minutes.

Some people make Changa by combining freebase DMT or another source of DMT with an MAO inhibitor, such as the ayahuasca vine (Banisteriopsis caapi). Changa is then smoked to provide a similar intensity of sensation but with a slightly longer duration of effects (up to 1 hour).

Read more from Related post: How to Make DMT at home

How Long Does DMT Stay in Your System?

DMT is rapidly degraded by the human body and is not kept anywhere in the body. It is completely removed from the body within a few hours.

DMT may be detected in the blood for up to 2 hours, saliva for 12 hours, urine for 24 hours, and hair for 3 months.

How Long Does DMT Stay in Blood?

DMT is removed from the blood within two hours.

The enzyme MAO converts DMT into inactive metabolites, which are subsequently filtered into the urine by the kidneys. The majority of this occurs within the same 45-minute period when the DMT is active. The effects fade because the DMT is degraded and eliminated from circulation.

However, it might take up to two hours for all DMT levels in serum (blood) to fall below the detection threshold.

How Long Does DMT Stay in Saliva

It’s uncertain how long DMT stays in the saliva, although it’s unlikely to be noticeable for more than 12 hours. DMT will usually be undetectable by 4 or 5 hours.

Saliva was shown to be a particularly helpful approach for measuring the concentration of DMT in the body after drinking ayahuasca in one research, but only if tested within an hour after drinking the ayahuasca brew.

Saliva testing is more helpful for identifying DMT concentrations during a trip than for detecting DMT after it has been used.

How Long Does DMT Stay in Urine?

DMT and its metabolites can be found in urine for up to 24 hours.

DMT is metabolized by MAO into inactive components, which are then transported into the urine via the kidneys and sit in the bladder until it is emptied. This is why DMT may be detected in urine for several hours longer than in blood.

How Long Does DMT Stay in Hair?

DMT may be detected in the hair for the longest time – up to 90 days.

Hair analysis testing, on the other hand, is unreliable and is rarely utilized alone.

Hair testing can reveal DMT usage from several months ago, but only in persons who have used DMT for a long time.

If you’ve taken DMT once or twice in the last three months, hair analysis is unlikely to reveal the presence of DMT or its metabolites.

Will DMT Make Me Fail A Drug Test?

Drug testing can only detect what they are searching for. DMT is seldom, if ever, in the list of chemicals being tested.

Having said that, DMT remains a Schedule I substance in the United States. It is certainly conceivable for government authorities or police departments to investigate DMT use.

Fortunately, DMT does not last in the body for long. You’re unlikely to register any DMT on the test if you’re not tripping on DMT within around 24 hours of your drug screening.

DMT users frequently fail drug tests based on hair analysis.

How To Get DMT Out of the Body Faster

There are a few things you can take to assist DMT in leaving your body faster.

Drink Water & Diuretic Teas

DMT is mostly excreted through the urine, thus consuming plenty of fluids or using diuretics will help speed up the process.

Some good (safe) natural diuretics include:

  • Tea from dandelion (Taraxacum officinale)
  • Equisetum arvense (Horsetail)
  • Petroselinum crispum (parsley)

Avoid MAO Inhibitors

It’s also critical to avoid using MAO inhibitors before or after taking DMT. Some antidepressant drugs, such as Nardil, Parnate, or Emsam, function by blocking MAO. DMT should never be used if you are already on drugs, but it is especially vital to avoid it if you are using MAO inhibitors.

There are other natural MAO inhibitors to avoid if you want to get DMT out of your system as rapidly as possible:

  • Piper methysticum (Kava)
  • Passiflora incarnata (Passiflora incarnata)
  • Piper nigrum (black pepper)
  • Phellodendron amurense (Amur Cork Tree)
  • Glycyrrhiza uralensis (licorice)

Take Calcium Supplements

Calcium has been demonstrated to increase monoamine oxidase activity.

This impact is being explored particularly in the context of Alzheimer’s disease, but it may also be significant for DMT elimination. You may also receive a lot of calcium by consuming calcium-rich foods like dairy, eggs, soy, and green leafy vegetables.

DMT Metabolism 101

MAO and peroxidases both rapidly metabolize DMT.

MAO converts DMT to DMT-N-oxide (DMT-NO) and indole-3-acetic acid (IAA), as well as trace quantities of N-methyltryptamine (NMT), 6-hydroxy-DMT (6-OH-DMT), and 6-OH-DMT-N-oxide (6-OH-DMT-NO).

DMT is metabolized differently by peroxidases, which convert it into 1,2,3,4-tetrahydro-beta-carboline (THBC), 2-methyl-THBC, hydroxy-DMT, N, N-dimethyl-N-formyl-kynuramine, and N, N-dimethyl-kynuramine.

When fed to animals, the only metabolite demonstrated to have psychoactive effects is NMT; the others have no psychoactive impact profiles.

These secondary chemicals are eliminated through the urine after they have been metabolized. A very small amount of DMT is eliminated unaltered in urine.

Key points: How Long Does DMT Last?

Unless the metabolic pathways are inhibited by an MAO inhibitor, DMT is a relatively short-lived psychedelic.

DMT is seldom active for more than 30 minutes after being smoked, vaped, injected, or insufflated (snorted). Some aftereffects may last up to 45 minutes, but no longer.

Ayahuasca is the most potent form of DMT. It is created by mixing a DMT supply with a natural MAO inhibitor. DMT may be detected in the blood for up to 2 hours, saliva for up to 12 hours, and urine for up to 24 hours. Hair analysis may be able to identify DMT months after usage, but only if it is routinely used. One or two doses of DMT are unlikely to register on any drug test if at least a day passes between the dosage and the drug test.


  1. T. M. Carbonaro and M. B. Gatch (2016). N, N-dimethyltryptamine neuropharmacology. 126, pp. 74-88 in Brain Research Bulletin.
  2. Lanaro, R., Mello, S. M., da Cunha, K. F., Silveira, G., CorrêaNeto, N. F., Hyslop, S.,…, and A. Linardi. In a religious environment, the kinetic profile of N, N-dimethyltryptamine, and carbolines in saliva and serum following oral consumption of ayahuasca. Testing and analysis of drugs.

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