1P-LSD: Everything You Should Know. Is it Safe?

You’ve probably heard of LSD (lysergic acid diethylamide). Along with the primary element in magic mushrooms, psilocybin, it is the classic psychedelic drug. 1P-LSD

What you may not be aware of is that there are dozens of LSD analogs that have nearly comparable effects.

One such analog is 1P-LSD. The chemical change is minor, and a new study reveals that 1P-LSD is a prodrug of LSD. This implies that when you consume 1P-LSD, it gets converted to LSD, resulting in psychedelic effects.

It is permitted in Canada but remains illegal in the United States.

Everything you need to know about 1P-LSD is right here.

What is 1P-LSD?

1P-LSD is an abbreviation for 1-propionyl-lysergic acid diethylamide. It’s an LSD derivative, which implies it’s a tweaked version of the famous LSD-25 developed by Albert Hofmann in 1943.

A propionyl group connected to the nitrogen molecule in the indole part of LSD distinguishes this molecule from LSD. The core indole molecule of LSD is the molecule that is shared by all other tryptamine-based psychedelics (such as DMT or psilocybin).

1P-LSD is only moderately psychedelic on its own. It possesses a 67-fold lower affinity for 5-HT1A receptors, a 13-fold lower activity at 5-HT2A receptors, and a 3.5-fold higher activity at h5-HT2C receptors than LSD-25. However, because 1P-LSD is a prodrug for LSD, it is converted to LSD by the liver and subsequently produces psychedelic effects. LSD from 1P-LSD is almost 100% bioavailable.

Specifications and Technical Information

Active Ingredient	1-propionyl-lysergic acid diethylamide
Level of Risk	Low
Other Names	Legal Acid
Most Common Side-Effects	Anxiety & paranoia
Duration of Effects	7 – 11 hours
Legality	Not Scheduled In Most Countries (Legal Grey-Area)

Summary of 1P-LSD Harm Reduction and Responsible Use:

I understand why psychedelics must be approached with caution.
I am aware of the 1P-LSD legislation in my nation and state.
I’m comfortable with and confident in the dosage I’m using.
I used a drug-testing kit to test a sample of the substance I was consuming.
I’m not using any drugs or other substances in conjunction with 1P-LSD.
I’m in a secure and comfortable setting with individuals I trust.
One of my group members is responsible and sober (also known as a trip sitter).
I have nothing big planned after the trip.
I’m in a good and healthy mental condition.
Set, setting, sitter, and drug are the four pillars of appropriate psychedelic usage that I know of.
Understand the timetable — the effects of 1P-LSD will last between 7 and 11 hours.

Where Did 1P-LSD Come From?

Since the decriminalization of LSD and other psychedelics in 1966, scientists have been on the lookout for new psychedelic “research chemicals” or “designer drugs.”

Over the years, researchers such as Alexander Shulgin and Dr. David E. Nichols (Purdue University) have achieved significant advances.

It’s unknown who created 1P-LSD or when it was discovered, but the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) first reported it in 2015.

This substance first appeared on the market as a “legal LSD alternative” in the mid-2010s, with no prior mention in scientific literature. Whoever invented it did not publish anything about it and has not claimed credit for their invention.

LSD Analogs and Derivatives

1B-LSD
1cP-LSD
AL-LAD
ALD-52
ETH-LAD
LSM-775
LSZ
PRO-LAD

What’s The Dose of 1P-LSD?

The dosage of 1P-LSD is the same as LSD. No investigations on the effective dosage of 1P-LSD have ever been conducted.

However, given recent results that 1P-LSD is virtually completely converted to LSD, the psychoactive dosage would be the same:

10-20 micrograms is a microdose.
25-40 micrograms is the recommended starting dose.
The typical psychoactive dose is 80-200 micrograms.
200-400 micrograms Heroic Dose

What Does 1P-LSD Feel Like?

The effects of 1P-LSD are almost identical to those of LSD. The only difference is that the effects may take a little longer to take effect. This is due to the fact that 1P-LSD must first be digested by the liver and converted into LSD.

Depending on your own mental state, the experience might differ greatly. If you’re already sad or nervous before the encounter, 1P-LSD will amplify these feelings. Similarly, if you are eager, optimistic, and interested, 1P-LSD will enhance this state of awareness even further.

This is why the concepts of set (mindset) and setting (the surroundings and people with whom you are traveling) are so crucial. Going into the event with a negative mindset, such as fear, worry, or depression, may result in a more difficult experience and may even cause psychological injury.

The positive effects of 1P-LSD :

A powerful emotion of amazement and wonder
Time perception has been altered.
Experiences that are cathartic
Extensive and insightful experiences
Ego-dissolution
Euphoria
Hallucinations
Laughter
Mystical encounters
Remembering important life occurrences
Synesthesia

The negative effects of 1P-LSD:

Anxiety
Believing that others are “out to get you”
Confusion and dissatisfaction when carrying out ordinary chores
Feelings of being swamped
Paranoia
Reliving unpleasant experiences from the past
Psychosis or other mental disorders precipitation

How Long Does 1P-LSD Last?

1P-LSD has a similar half-life as LSD (6 to 10 hours).

It is transformed to LSD after consuming 1P-LSD. This happens rapidly, but it increases the amount of time it takes for the benefits to emerge. LSD typically takes less than 30 minutes to take effect, however 1P-LSD might take up to an hour and a half (generally less than an hour). This also adds to the overall length of the journey.

When you account for this discrepancy, the expected duration of effects for acid is 6 to 10 hours, which implies 1P-LSD is around 7 to 11 hours.

How to Take 1P-LSD

1P-LSD is administered in the same manner as LSD. It’s spread out on a square of blotter paper and then kept under the tongue for 10 to 15 minutes before being swallowed completely.

The active components are absorbed directly into the circulation via the capillaries under the tongue.

Most individuals keep LSD under their tongue for a speedier onset of effects since it enters the circulation immediately rather than passing through the digestive tract first.

If you swallow the tab instead, the 1P-LSD may kick in faster.

This is due to the fact that, unlike acid, this psychedelic must be activated by the liver. When molecules like these are absorbed by the stomach, they are sent straight to the liver, which performs “first-pass metabolism.”

How Strong is 1P-LSD Compared To Other Psychedelics?

1P-LSD is one of the most potent psychedelics on the planet, gram for gram. This designation is shared by all psychoactive LSD compounds that are strongly psychoactive at submilligram dosages.

For example, the dosage of 1P-LSD is approximately 200 micrograms, or 0.2 milligrams. Compare this to the active element in magic mushrooms, psilocybin, which is closer to 10 milligrams. The active substance in the Bufo alvarius toad (another potent psychedelic) is roughly 8 milligrams, whereas N,N-DMT, the main element in ayahuasca, is over 50 milligrams.

1P-LSD vs. LSD-25

LSD-25 is the original form of LSD, created by Albert Hofmann in the 1940s. It’s the compound that folks like Timothy Leary, Richard Alpert (Ram Dass), Nicolas Sand, Tim Sully, Ralph Metzner, and others popularized in the 1960s and beyond.

1P-LSD is nearly indistinguishable from LSD-25. According to some studies, 1P-LSD is weaker, while others claim it is stronger. In terms of effects and dose, the two are thought to be equivalent.

1P-LSD vs. AL-LAD

AL-LAD (N6-allyl-6-norlysergic acid diethylamide) is another LSD-25 derivative with a chemical structure comparable to 1P-LSD.

The dosage and overall experience are nearly identical, with a few minor subjective variances.

AL-LAD, for example, is supposed to be a more mellow form of acid. It is more visually appealing, but less contemplative. This implies it will be simpler to manage philosophically and less likely to result in concerns with ontological shock or existential dread — both of which can come from the psychedelic experience.

1P-LSD vs. LSA

The active element in Hawaiian baby Woodrose and morning glory vine is LSA (lysergic acid amide). It has effects comparable to LSD derivatives such as 1P-LSD, but with a few important distinctions.

For one thing, LSA is less effective than 1P-LSD. The typical psychoactive dose is roughly 800 micrograms, as opposed to 200 for 1P-LSD.

Second, the LSA experience is more clear and sedative than introspective and psychedelic. It frequently causes people to go asleep, where they have intricate, vivid, and unforgettable dreams. Even when I’m awake, the encounter feels dreamy.

1P-LSD vs. ALD-52

1P-LSD is a homolog of ALD-52, which means it is almost similar except for an additional carbon atom.

1P has a propionyl group linked to the nitrogen atom in the indole group, whereas ALD-52 has an acetyl group.

These two compounds have nearly comparable actions.

1P-LSD vs. ETH-LAD

ETH-LAD (6-ethyl-6-nor-lysergic acid diethylamide) is the most potent of the lysergamide psychedelics (though this is debatable).

When consumed at the same dose, ETH-LAD is thought to be around 20% stronger than 1P-LSD. It has more powerful images and creates a strong sense of connection and reflection.

The disadvantage of this chemical is that it might induce some unpleasant physical side effects, such as stomach distress and increased urine. This might cause beginner users to worry and have a more difficult trip.

As a result, ETH-LAD is not suitable for persons who are new to psychedelics. For these folks, 1P-LSD is a preferable alternative because it is less likely to create a “bad trip.”

1P-LSD vs. PRO-LAD

Dr. David Nichols and his colleagues at Purdue University developed PRO-LAD (6-propyl-6-nor-lysergic acid diethylamide) somewhere in the early to mid-1980s.

This molecule is somewhat weaker than 1P-LSD, although most individuals will be unable to distinguish between the two psychedelics.

According to multiple trip reports, the key distinction is that PRO-LAD has a stronger body-high component than 1P-LSD.

1P-LSD vs. LSZ

The second most powerful lysergamide psychedelic is LSZ (lysergic acid 2,4-dimethylacetamide). It has the same efficacy as ETH-LAD but is less prone to have physical negative effects.

LSZ delivers a more “emotional” experience than 1P-LSD. Many persons who use this psychedelic report feeling a profound connection to and empathy for others.

This effect is also seen with 1P-LSD, but not as strongly.

Is 1P-LSD Safe?

There have been no clinical trials on 1P-LSD to demonstrate its safety in people, and it has only been on the market for a few years.

Having said that, there have never been any known incidences of toxicity or mortality linked to this chemical. Preliminary study indicates that it has a similar effect profile and safety as LSD-25 — a chemical with extensive research confirming its high safety incidence.

Responsible Use of Psychedelics

It is vital, as with all psychedelics, that you learn how to be safe with these substances before you begin. While there is little chance of physical adverse effects, these drugs pose a risk of psychological injury.

Before using psychedelics, those with a history of psychosis, schizophrenia, or other mental illnesses should always see a psychologist. While there is some evidence that these chemicals can aid in the treatment of mental illnesses, this must be done in a controlled setting under the supervision of a psychotherapist. Due to a paucity of clinical studies, it is more likely that LSD-25, psilocybin, or 5-MeO-DMT will be employed instead of 1P-LSD in this context.

Risk of Adulteration

One of the advantages of 1P-LSD is that it has fewer legal constraints. While not legally legal, this psychedelic is not unlawful (in most areas). This implies that finding a legitimate supply is easier than it is for obviously forbidden chemicals. You may buy 1P-LSD from trustworthy companies like Sigma Aldrich or other brand name vendors, which reduces the possibility of adulteration with potentially hazardous substances.

You don’t have to buy things on the black market. Blackmarket sellers significantly raise the risk of purchasing fake LSD, which frequently uses deadly NBOMe chemicals instead. Many people have died as a result of this substance in the past.

Regardless of where you get 1P-LSD, you should test it with a reagent drug testing kit.

How to Test 1P-LSD

Because you just need a tiny sample to conduct this efficiently, you’re not wasting any money or dosages. The test requires only a little slice of one of your tabs.

Substance testing will not tell you the quality of a tab, but they will tell you whether or not particular substances are present. LSD and its analogs, NBOMe, and DOMx substances are the only harmful drugs powerful enough to fit on a single blotter paper.

It’s always a good idea to do repeated LSD and 1P-LSD drug tests. The ideal would be to run all four, but if you can only run one or two, the Ehrlich and Marquis are the most crucial.

1. Ehrlich Test

This will tell you whether the tab includes or does not contain indole alkaloids (LSD, 1P-LSD, AL-LAD, or other variants).

This is the test to run if you only run one.

Wait for one drop to change color on a little slice of the tab. It should darken to purple or pink. LSD-25 normally transforms on the spot, however, 1P-LSD takes a little longer (up to 3 minutes).

If there is no color change, your sample most likely lacks indole alkaloids and is therefore dangerous to use.

2. Marquis Reagent

Amphetamines, NBOMe, mescaline, and other chemicals in your sample will be identified using the Marquis reagent. If it becomes green, it includes NBOMe molecules and should be discarded.

For the identification of additional chemicals, refer to the chart contained in your Marquis test kit.

3. Hofmann Reagent

To be sure, it’s usually a good idea to conduct two or more tests with different reagents. The Hofmann reagent is used to distinguish between various indole alkaloids.

If the sample becomes purple, it is almost certainly an LSD derivative. It’s 5-MeO-DMT if it goes green; N,N-DMT if it turns yellow.

4. Mecke Reagent

The Mecke reagent’s primary function is to detect the presence of opiates in the sample. Most opiates aren’t powerful enough at sub-milligram dosages, and the sensation of these substances is nothing like LSD, therefore there aren’t likely to be any opiates in the sample.

This is a precautionary test. It is simple to do the Mecke test to ensure that the sample does not include ultra-potent versions of opiates such as fentanyl or kar-fentanyl.

If the Mecke reagent becomes blue, it indicates that the material contains opioids and should be avoided.

Is 1P-LSD Legal?

1P-LSD is not technically classified as a prohibited drug in either Canada or the United States.

This drug is available for purchase online in both countries. In Canada, being in possession of this chemical is unlikely to result in any legal issues.

Because of its similarities to LSD-25, the DEA in the United States may deem 1P-LSD unlawful under the Federal Analog Act. However, no one has been convicted of possessing 1P-LSD, and the DEA has never formally addressed or made any remarks about it.

Some European nations have added 1P-LSD to their list of banned chemicals, including:

France
Finland
Denmark
Germany
Spain
Japan
Latvia
Norway
Romania
Sweden
Australia
The United Kingdom
Canada

Conclusion: What’s The Future of 1P-LSD?

This psychoactive drug has nearly equivalent effects to LSD. It’s a prodrug of LSD-25, which means it’s metabolized by the liver into LSD, which subsequently produces psychedelic effects.

Because LSD is illegal, but 1P-LSD is not (in most areas), it is used in the same way.

As additional nations learn about this analog, they will most likely place it under the same rules as LSD.

More liberal countries, like as Canada, are unlikely to make this move because laws are already in the process of legalizing LSD. This substance is not hazardous, and there is no evidence that it will represent an extra risk to society. Until LSD-25 becomes legal, we’re likely to see more of this molecule.

LSD-25 is less difficult to synthesize and has a faster onset time than 1P-LSD. When the two have the same experience, LSD is the somewhat superior choice.

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1P-LSD: Everything You Should Know. Is it Safe?